A major highway linking the two cities is to close for two weeks while the state Department of Transportation works to replace a roadbed that has collapsed, authorities said on Monday.
The King George, a six-lane highway that runs through Kingman, has become a major thoroughfare on the Interstate 10 corridor linking Los Angeles and Anaheim.
It is a major artery for people and freight travelling north.
State transportation officials have said the highway could reopen by the end of the week.
The collapse of the roadbed has left a section of the highway wide open, blocking a major freeway artery for several hours on Monday afternoon.
The roadbed, which connects two separate areas, collapsed about 30 minutes before midnight, Los Angeles Fire Department spokesman Matt Coughlin said.
There were no immediate reports of injuries.
Los Angeles Mayor Eric Garcetti said he would call on the state to pay $2.5 million to the Kingman city, which is about a half-hour north of Los Angeles.
The highway was built in 1960, and is one of the busiest freeways in the country, connecting major US cities such as Houston and New York.